ii) The classical subtype was strongly associated with the astrocytic signature and contained all common genomic aberrations observed in GBM, such as chromosome 7 amplifications, chromosome 10 deletions, EGFR amplification, deletion of the TP53-stabilising isoform of the cyclin-dependent inhibitor CDKN2A/ARF. The gene discussed is CDKN2A; the disease is glioblastoma.