MAPK8 and glioblastoma: Characteristic features of CBD-induced signaling in glioblastomas represent the consequences of oxidative stress [40] and include the early induction/ upregulation of JNK-cJUN and modulation of MAPK p38-ATF2 signaling pathways and the late downregulation of the levels of an active phosphorylated form of AKT and ERK involved in regulation of cell proliferation and survival (Figure 13C).