We previously observed the endogenous TRAIL secretion by glioma cells in cell cultures [22] that could result in TRAIL-mediated apoptosis via an autocrine/paracrine mechanism in TRAIL-R2/DR5 positive glioblastomas with upregulated surface expression of this death receptor and suppression of phospho-AKT levels after CBD treatment. This evidence concerns the gene TNFSF10 and central nervous system cancer.