Interestingly, CDDP treatment has previously shown to upregulate important ligands for NK cell-mediated eradication of tumor cells, including androgen receptor-UL16-binding protein 2 (ULBP2) and MHC class I chain-related molecule A and B (MICA A/B) in hepatocellular carcinoma and NSCLC, respectively [19, 20]. This evidence concerns the gene JAML and hepatocellular carcinoma.