We found remarkable heterogeneity between primary and metastatic lesions with only a small subset of alterations present in both sites (Figure 2): WES of the primary tumor from patient 1 identified private mutations in the tumor suppressor genes PTEN and APC as well as in HRAS, BCAR1 (COSM1479104), and SETD1A (COSM126103). This evidence concerns the gene PTEN and neoplasm.