Analysis of human GBM and normal brain data from TCGA datasets revealed that mRNA levels of GFRA1, RET, NCAM1, CDH2, SDC3 and ATRN were comparable ( p>0.05), whereas mRNA levels of Integrin beta-1 (ITGB1), NRP1 and NRP2 were elevated in the GBM brains (P<0.01, FC>1.5; Figure 3). The gene discussed is ITGB1; the disease is glioblastoma.