HSF1 and cancer: The oncogenic roles of HSF1 center on its function as a transcription factor to upregulate genes that support the malignant state [34], which includes its classical role of promoting cell survival by protection of the proteome [3], promoting glycolysis typical of cancer cells [14, 35], regulating translation [35], and promoting a malignant tumor microenvironment [36] among many other functions [3].