Cysteine cathepsins, as well as legumain, a cysteine endopeptidase of the asparaginyl endopeptidase family, are reportedly secreted into the extracellular milieu by tumor or tumor associated cells of the tumor microenvironment, where they promote tumor progression and metastasis through complex processes involving cleavage, processing, or shedding of signal molecules and extracellular matrix proteins [10, 46]. Here, LGMN is linked to neoplasm.