Klempner et al. reported three EGFR-mutated NSCLC patients with RET-fusion genes that were concomitantly detected with the original EGFR mutation after acquisition of resistance to EGFR TKIs (two cases with CCDC6-RET and one case with NCOA4-RET) [24]. The gene discussed is NCOA4; the disease is non-small cell lung carcinoma.