Our recent demonstration that an HFHC diet induces hepatic protein kinase C beta (PKCβ) expression, whereas PKCβ deficiency sensitizes mice to hepatic cholesterol accumulation, suggests that PKCβ has the potential to modulate inflammation, nonalcoholic steatohepatitis (NASH), and HCC [14–16]. The gene discussed is PRKCB; the disease is hepatocellular carcinoma.