The univariately associated variables with MACE were Hsp-27 > 45 ng/mL (HR 2.945, 95% CI 1.839–6.451, P < 0.001), dyslipidemia (HR 1.780, 95% CI 1.307–2.280, P = 0.046), hypertension (HR 1.759, 95% CI 1.314–2.029, P = 0.025), DM (HR 1.212, 95% CI 1.012–1.968, P = 0.045), cTnI (HR 1.232, 95% CI 1.105–1.809, P = 0.048), smoking (HR 1.748, 95% CI 1.340–3.148, P < 0.001), high thrombus burden (HR 2.665, 95% CI 1.540–5.276, P < 0.001), aspirin (HR 0.709, 95% CI 0.326–0.854, P = 0.026), statins (HR 0.469, 95% CI 0.203–0.814, P = 0.021), ARB (HR 0.356, 95% CI 0.108–0.614, P = 0.018) (Table 3). The gene discussed is TNNI3; the disease is diabetes mellitus.