Further, based on our pervious finding that serglycin can promote the adhesion of myeloma cells to bone marrow stromal cells (BMSCs) and collagen I, we also tested the impact of SRGN exosomes and SRGN-null exosomes on myeloma cell adhesion towards BMSCs and collagen I. As expected, SRGN-KD CAG myeloma cells showed significantly less adhesion to BMSCs and collagen I compared to control CAG cells (Figure 3B). Here, SRGN is linked to plasma cell myeloma.