In this study, we found that TSP-1, TGF-β1, CTGF and VEGF, as four angiogenic factors in the supernatants of the RA-FLS and HDMECs co-culture, were systematically up-regulated compared with those in the NH-FLS and HDMECs co-culture medium. Here, TGFB1 is linked to rheumatoid arthritis.