In conclusion, mGITRL-FP administered prior to the rMVA/rF-CEA-TRICOM vaccine elicits specific changes in immune cell subsets (i.e., reduction of CD4+FoxP3+ regulatory T cells/repopulation of T effectors) within the tumor microenvironment both of which support a robust and durable antitumor response. Here, CEACAM5 is linked to neoplasm.