HAND2 has a BORIS site at its promoter and is known to be aberrantly methylated in CLL [67], which may indicate an activity of BORIS counteracting aberrant hyper methylation, similar to TP53TG1. While HAND2 was shown to be a player in differentiation and trans-differentiation [68], it shows low expression in K562 and a relatively minor increase. This evidence concerns the gene CTCFL and B-cell chronic lymphocytic leukemia.