Using a previously established method for determining bimodality [27], we found that the expression of these genes were bimodally distributed in both SCLC cell lines (bimodal index (BI) 2.34 and 1.86, for TTF1 and cMYC respectively) and patient tumors (1.85 and 1.55, respectively) (Supplementary Figure 7). Here, MYC is linked to small cell lung carcinoma.