In addition, exogenous application of the CXCR3 ligand CXCL10 to tumor tissues, or ectopic expression of CXCL10 by tumor cells, has been demonstrated to increase the number of tumor-infiltrating NK cells expressing CXCR3 and to prolong NK cell-dependent survival in mice [27]. The gene discussed is CXCR3; the disease is neoplasm.