Otherwise, as our network analysis revealed, NOTCH1 mutations can explain an enhanced production of eosinophilia through a multifaceted role: regulating the cytokines that induce eosinophil lineage commitment and prolong eosinophil survival (IL-5 and CSF2), regulating the proteins that induce eosinophil tissue migration (PTGDS), and affecting hematopoietic stem cell level for eosinophil lineage commitment (SPI1). Here, CSF2 is linked to Increased total eosinophil count.