SPI1 and Increased total eosinophil count: Otherwise, as our network analysis revealed, NOTCH1 mutations can explain an enhanced production of eosinophilia through a multifaceted role: regulating the cytokines that induce eosinophil lineage commitment and prolong eosinophil survival (IL-5 and CSF2), regulating the proteins that induce eosinophil tissue migration (PTGDS), and affecting hematopoietic stem cell level for eosinophil lineage commitment (SPI1).