The homozygosity for DRB1*04:05-DQB1*04:01 (OR 5.07, 95% CI 1.69–15.20) conferred slightly higher OR for AIH than heterozygosity for DRB1*04:05-DQB1*04:01 (OR 3.81, 95% CI 2.76–5.28). This evidence concerns the gene HLA-DRB1 and autoimmune hepatitis.