Taken together, the present data do not suggest a driver function of somatic PIK3C2B mutations in NSCLC-SCC and that aberrant PI3K pathway activation in NSCLC-SQCC occurs through alterations in more central compartments of the signaling axes like EGFR, PIK3CA and PTEN (25). This evidence concerns the gene PIK3C2B and non-small cell lung carcinoma.