Perhaps even more importantly, since it also shares similar substrates with the A Disintegrin and Metalloproteinase (ADAM) family of enzymes (the main group of enzymes that act as α-secretase to physiologically cleave the amyloid precursor protein (APP) in the so-called non-amyloidogenic pathway [101]), it could be directly involved in the metabolism of the amyloid precursor protein (APP) in the very early stages of AD. Here, APP is linked to Alzheimer disease.