In the revised WHO classification from 2016 [1] cell of origin (COO) [2], double-hit (DH) MYC+BCL2/BCL6 translocations [3] and double expression (DE) of MYC and BCL2 protein [4;5] were pointed out as the currently most established and important biomarkers in DLBCL. Here, MYC is linked to diffuse large B-cell lymphoma.