We subsequently evaluated the level of NEU3 expression in the two NSCLC cell lines in comparison to the quantity observed in the normal mucosa cell line and we found that none of the two NSCLC cells displayed intrinsic NEU3 overexpression, thus rendering these two models suitable to the perturbation of NEU3 expression through transfection with a plasmid able to lead to a constitutively overexpression of such a sialidase. This evidence concerns the gene NEU3 and non-small cell lung carcinoma.