PCSK9 and familial hypercholesterolemia: Familial Hypercholesterolemia (FH) is considered to be a genetic disorder of lipid metabolism attributed to defects in the LDL-receptor (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin type 9 (PCSK9), and LDL receptor adaptor protein 1 (LDLRAP1)[1].