Results of the univariate and multivariate logistic regression models on the risk of a LSIL/HSIL cytologic finding are summarized in Table 3 (Model 1): subjects with a lower CD4+/CD8+ ratio, with multiple HR-HPV genotypes and with a previous diagnosis of syphilis or AIDS were more likely to have LSIL/HSIL. The gene discussed is CD4; the disease is AIDS.