According to the idea that the prevention of immune cell infiltration is an immune evasion mechanism, tumors with higher infiltration of tumor infiltrating lymphocytes (TILs) have a better prognosis, and inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1 and IFNγ regulate EC adhesion molecule expression, thus further controlling immune cell infiltration [3]. Here, TNF is linked to neoplasm.