Considering the proposed glycoprotein complex requirements for the FB and EC pathway of HCMV infection and the neutralization capacity of antibodies targeting the glycoproteins (Figure 1), it can be assumed that NAb targeting epitopes of gB, gH/gL/gO or gM/gN can broadly interfere with HCMV host cell entry and hence potentially contribute significantly to the protection against HCMV infection. The gene discussed is PPP1R3A; the disease is cytomegalovirus infection.