While NAb targeting the essential envelope glycoprotein complexes composed of gB or gH/gL/gO can effectively interfere with HCMV infection of both FB and EC infection, NAb mainly recognizing conformational epitopes of UL128/130/131A subunits of the PC are exceptionally potent to specifically block EC infection. The gene discussed is ERVW-1; the disease is cytomegalovirus infection.