In this study, several genes including Gdpd2, Spon2, Pon1, Scgb3a2, Ighv2-3, Sult1d1, Cyp2f2, Npas2, Arntl, and Igkv4-68 were down-regulated in OVA-challenged mice compared with control mice, may be useful as biomarkers of asthma. Here, SPON2 is linked to asthma.