Diabetic WT mice also exhibited significant increase in Sirius Red staining for collagen I and III in the interstitial spaces (Fig. 3d, e), indicating the development of renal fibrosis, while kidneys from diabetic Anxa1−/− mice had significantly more Sirius Red staining specifically in the interstitial spaces and around the vasculature (Fig. 3d, e). The gene discussed is ANXA1; the disease is renal fibrosis.