The main indication for LAAC in both groups was previous major bleeding (n = 47 (47%) for ACP versus n = 50 (52%) for Amulet; p = 0.57), followed by previous minor bleeding (n = 42 (42%) for ACP versus n = 30 (31%) for Amulet; p = 0.10) and renal or hepatic disease (n = 34 (34%) for ACP versus n = 34 (35%) for Amulet; p = 0.92)—none presented significant difference (Table 2). This evidence concerns the gene NDUFAB1 and liver disorder.