NFKB1 and neoplasm: In addition to our data, previous study showed that mannosylated polymer nanoparticles specifically and effectively delivered siRNA to tumor associated macrophages (TAMs) (Ortega et al., 2015) and made the encapsulated siRNA more capable to manipulate NF-κB signaling in the tumor (Ortega et al., 2016); and man-chitosan nanoparticles effectively enhanced the transfection efficiency of DNA and lowered the toxicity of chitosan in peritoneal macrophages (Hashimoto et al., 2006).