Taken together, our results on cellular systems suggest that during Helicobacter infection the pre-existing TFF1 favors the induction of TFF2 and TFF1 itself, known as gastric protective factors, while limits the up-regulation of TFF3, a negative marker in this district, as well as the cytokine response (IL-8 and IL-6). The gene discussed is TFF2; the disease is Helicobacter pylori infectious disease.