These observations, together with clinical data, led to consider TFF1 as a specific gastric tumor suppressor, although recent studies clarified that its expression is reduced only in the intestinal-type gastric cancers (Im et al., 2013), contrary to patients with diffuse and undifferentiated cancer type characterized by high TFF1 expression (Ren et al., 2006). The gene discussed is TFF1; the disease is gastric neoplasm.