We have previously reported immunohistochemical studies in animals exposed to KA, and an increase in the immunoreactivity of MT in the cytoplasm of astrocytes CA1, CA3, and dentate gyrus of the hippocampus was observed (Figure 5), as well as a significant increase in expression of MT-I and MT-II between 6 and 24 h after KA injection; these results contributed by our group strongly support the evidence that MT plays a major role as an early expression protein in epileptic seizure models [101]. The gene discussed is MCAT; the disease is Seizure.