Previously, we compared miRNA expression profiles of BM-derived macrophages (BMDMs) from RBP-J-deficient and control mice, and demonstrated that miR-125a mediates Notch signaling to regulate M1/M2 macrophage polarization, and converts tumor-associated macrophages (TAMs) into M1-like macrophages to suppress tumor growth (18). Here, RBPJ is linked to neoplasm.