In particular, several recent papers have reported that miR-148a-3p-mediated inhibition of Pten participates in glomerular cell proliferation in lupus nephritis (28), osteosarcoma cell growth (29), and immature B cells survival (30), suggesting that miR-148a-3p can regulate inflammation-related diseases by targeting Pten. Given the important role of macrophages during inflammation initiation and progression, the results of the current study show that miR-148a-3p can promote inflammatory responses of LPS/IFN-γ-stimulated M1 macrophages by modulating PTEN/AKT/NF-κB signaling. This evidence concerns the gene IFNG and osteosarcoma.