SOCS1 and renal fibrosis: Intraperitoneal administration of SOCS1 peptidomimetic (53DTHFRTFRSHSDYRRI68), which is a peptide that mimics the activity of the SOCS1 KIR region, in mice with diabetic nephropathy suppressed the activation of STAT1 signals, reduced serum creatinine and albuminuria levels, and ameliorated mesangial expansion, tubular injury, and renal fibrosis (77).