Eμ-SOCS1–/– mice express only a limited level of SOCS1 in their peripheral lymphocytes, thus allowing the excessive activation of STAT1, development of multiple organ inflammation, spontaneous activation of lymphocytes, production of autoantibodies such as anti-dsDNA IgG, and development of prominent glomerulonephritis, which are all reminiscent of murine lupus models (36). This evidence concerns the gene SOCS1 and glomerulonephritis.