HP and infection: We focused our attention on miR-4459 and miR-4270: the first because of the multiplicity of its targets and the second because predicted to target the most upregulated gene in macrophages infected with Hp, CD300E. For both miRNAs, we confirmed by qRT-PCR a downregulation of about 80% after 24 h and of about 50% after 72 h of infection (Figure 4A) and the activation of some of their targets (Figures 2 and 3), with respect to control cells.