CD8A and B-cell non-Hodgkin lymphoma: In agreement with a potential role of CXCR5+CD8+ T cells in the control of malignancies inside the lymphoid follicle, B cell lymphoma-bearing mice showed increased frequencies of CXCR5+CD44+CD8+ cells; in addition, B cells infected with murid herpes virus 4 (associated with B cell transformation) were also eliminated by this subset in vivo (17).