Our objectives in this study were to examine the frequency and significance of H-, K-, and N-RAS, TERT promoter and BRAF gene mutations in a large monocentric series of cytologically indeterminate thyroid nodules and to explore the utility (if any) of such a combined gene mutation analysis in terms of improving indeterminate thyroid nodule characterization prior to surgery. The gene discussed is BRAF; the disease is thyroid nodule.