As for the frequency and significance of BRAF mutations in cytologically indeterminate thyroid nodules, the percentage of mutated nodules in our series was 8%, which is slightly higher than reported elsewhere in the literature for indeterminate nodules, i.e., 5% in a recent meta-analysis on nine studies, and 6% in a large individual study published after the meta-analysis (18, 21). This evidence concerns the gene BRAF and thyroid nodule.