IUGR promoted deacetylation of histones H3 and H4 by recruiting HDAC1 and corepressor Sin3A; and histone 3 lysine 4 (H3K4) was demethylated and histone 3 lysine 9 (H3K9) was methylated, resulting in silencing of the PDX1. Here, PDX1 is linked to fetal growth restriction.