SERPINE1 and diabetic kidney disease: Losartan, an AT1R inhibitor, a common drug used in treatment of diabetic nephropathy has been shown to decrease H3K9/14Ac at RAGE, PAI-1, and MCP-1 promoters, in mesangial cells from db/db diabetic mice, suggesting that AT1R action may be also mediated by attenuation of epigenetic changes of the key genes involved in diabetic nephropathy.