Losartan, an AT1R inhibitor, a common drug used in treatment of diabetic nephropathy has been shown to decrease H3K9/14Ac at RAGE, PAI-1, and MCP-1 promoters, in mesangial cells from db/db diabetic mice, suggesting that AT1R action may be also mediated by attenuation of epigenetic changes of the key genes involved in diabetic nephropathy. Here, AGTR1 is linked to diabetic kidney disease.