CD8A and myeloid sarcoma: Lower EBV loads result in fewer chances of producing a memory B cell which recognizes a “forbidden” antigen present in the central nervous system, in turn reducing MS risk. Individuals with strong CD8+ (cytotoxic) T cell control of EBV would be at lower MS risk. Interventions to lower the general B cell population (e.g. anti-CD20 drugs) or the EBV infected B cell population (e.g. using adoptive immunotherapy) would both be expected to reduce MS risk