REN and preeclampsia: Although, the peripheral RAS (plasma levels of active renin, renin and Ang II) is downregulated in the DOCA preeclampsia model (Uddin et al., 2010); the association of gene polymorphisms of RAS and preeclampsia was observed in human, moreover, T allele of angiotensinogen may involve in the pathogenesis of PE (Aung et al., 2017).