APP is recognized to play an important role in the pathophysiology of AD, increasing the accumulation of Aβ in the CNS (Otsuka et al., 1991) and can directly be modulated by NF-κB (Chami et al., 2015) and TNF-α (Keller et al., 2013), that are also elevated in periodontal diseases. The gene discussed is TNF; the disease is Alzheimer disease.