Of these areas, both the basolateral and medial amygdala have been implicated specifically in the mediation of anxiety by Avpr1b (Salome et al., 2006), with evidence for additional modulation via the Oxtr (Litvin et al., 2011), while the Avpr1b in the LS is suspected to be involved in depressive states (Stemmelin et al., 2005). This evidence concerns the gene AVPR1B and Anxiety.