The target genes identified in cellular or disease signaling pathways were as follows: 50 genes in Wnt signaling pathway; 31 genes in TGF-beta signaling pathway; 27 genes in renal cell carcinoma; 27 genes in melanoma; 27 genes in colorectal cancer; 25 genes in glioma; 24 genes in p53 signaling pathway; 23 genes in pancreatic cancer; 15 genes in bladder cancer; and nine genes in the dorso-ventral axis formation (Fig. 4A). This evidence concerns the gene TP53 and central nervous system cancer.