EGFR and non-small cell lung carcinoma: To achieve complete EGFR endocytosis and avoid endosome arrest and EGFR recycling via EGFR-inhibited autophagy30, we stimulated A549 human non-small cell lung carcinoma cells with EGF under normal serum conditions, analyzed the canonical EGF-induced pathways of active EGFR in whole-cell lysate (WCL), and investigated whether EGF stimulation promoted the interaction between EGFR and sortilin.