It is also of interest that we found in this EWAS of the CHOP study, a methylation variant located in an unknown non-coding RNA LINC01115 located approx. 100 kb downstream of the ‘obesity gene’ TMEM18 that is expressed in the hypothalamus and has been linked with childhood obesity61, early onset extreme obesity62 and adult obesity6. Here, TMEM18 is linked to obesity due to melanocortin 4 receptor deficiency.