Interestingly, these proteins are known to associate with the long non-coding RNA Nuclear Paraspeckle Assembly Transcript 1 (Neat1) to form the paraspeckle, a nucleoplasmic compartment of approximately 0.2–1 μm in size with several physiopathological functions16, including nuclear retention of mRNAs21, transcriptional regulation22, cancer pathogenesis23, and viral infection24. This evidence concerns the gene NEAT1 and cancer.