These data suggest that the cross‐talk between Nox4 and Nox2: (1) is a phenomenon pertinent to transgenic as well as natural conditions; (2) seems to operate universally across species (mouse, rat, guinea‐pig, humans), and organs (heart or kidney), and under different models of oxidative stress (season, diabetes), and (3) may, as such, be of a functional importance although its mechanism remains elusive (see later). This evidence concerns the gene NOX4 and diabetes mellitus.