KLK3 and posterior cortical atrophy: In part, this will be due to the older age profile of men in UK GP compared with ProtecT participants, but it is also consistent with more tests in GP being undertaken to inform a diagnosis of LUTS, as LUTS are associated with elevated PSA levels (there is no reason to suppose a higher prevalence of non-symptomatic and undiagnosed PCa in CPRD or ProtecT GPs).