We found that siRNA-mediated silencing of BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), gelsolin (Gsn) and caveolin-1 (Cav1) diminished the growth and motility of mouse RCC (Renca) cells. This evidence concerns the gene BNIP3 and renal cell carcinoma.