BNIP3 and nonpapillary renal cell carcinoma: Paired box 8 (Pax8), a gene encoding a carcinogenesis-related transcription factor necessary for kidney development (Sharma et al., 2015), behaves in the opposite manner to Bnip3 in the comparative gene array, being downregulated in the ccRCC cohort but upregulated in the MM undergoing differentiation.