However, when Renca-YFP cells that have been transfected with Bnip3- or Cav1-specific siRNA were cultured as chimera organoids with wild-type MM cells, multiple Pax2-positive tubular structures and proximal tubes [aquaporin-1 (Aq1)+] were observed (Fig. 7I-P and Fig. 8I-P). The gene discussed is BNIP3; the disease is Miyoshi myopathy.