Among the caveolar-mediated endocytosis signaling genes induced in the MM that were also abundant in the ccRCC samples were galectin-3 (Lgals3), Gsn, Cav1, epidermal growth factor receptor (Egfr) and integrin beta2 (Itgb2) (Fig. 2A). Here, LGALS3 is linked to nonpapillary renal cell carcinoma.