Still, there is no universal pattern linking Cav1 expression in cancer cells and patient outcomes: high Cav1 levels are associated with poor prognosis and aggressive disease in melanoma, breast, prostate and lung cancer, whereas, at the same time, high Cav1 expression is correlated with good clinical outcomes in head and neck cancer and extrahepatic biliary carcinoma cells (Martinez-Outschoorn et al., 2015). Here, CAV1 is linked to melanoma.