LYPLAL1 and metabolic disease: Likewise, Lyplal1 expression was lower in kidney fat of Zucker diabetic fatty rats, compared with Zucker lean rats (Schmid et al., 2012), yet LYPLAL1 expression is increased in WAT from obese patients (Steinberg et al., 2007) and in the liver in mouse metabolic disease models (Ahn et al., 2016).