The results from Q-PCR and western blot indicated that the mRNA expression of E-cadherin and TTF-1 was downregulated, while the expression of fibronectin and α-SMA was increased in CCA tissues (Fig. 1a, b), which indicated that during the progression of CCA, the tumor cell exhibited activated MET phenotype. The gene discussed is FN1; the disease is cholangiocarcinoma.