The clinical expression of AP-2α in CCA was also estimated, and upregulated levels of AP-2α was found in tumor samples when compared to normal tissues (Fig. 3b), thereby suggesting that miR-200b could directly target TFAP2A, and downregulation of miR-200b might participate in the tumor metastasis via TFAP2A. The gene discussed is TFAP2A; the disease is cholangiocarcinoma.